No association of candidate genes with cannabis use in a large sample of Australian twin families
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene‐based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false‐positive findings in previous studies.
Document Type: Research Article
Affiliations: 1: Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia 2: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Publication date: 2012-05-01