Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence

Authors: Contet, Candice¹; Gardon, Olivier²; Filliol, Dominique²; Becker, Jérôme A. J.²; Koob, George F.¹; Kieffer, Brigitte L.²

Source: Addiction Biology, Volume 16, Number 4, 1 October 2011 , pp. 615-619(5)

Publisher: Wiley-Blackwell

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Abstract:

<title type="main">ABSTRACT</title>

Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysis identified 17 and 15 genes selectively induced or repressed, respectively, under conditions of excessive drinking. These genes belong to signaling pathways involved in neurotransmission and transcriptional regulation.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1369-1600.2010.00304.x

Affiliations: 1: The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, USA 2: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université de Strasbourg, France

Publication date: 2011-10-01