Skip to main content

MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

ABSTRACT

The aim of the present study was to investigate MAOA gene–environment (G*E) interactions in relation to adolescent alcohol consumption. In the county of Västmanland, Sweden, all 17–18-year-old students were asked to complete an anonymous questionnaire and provide a saliva sample during class hours. A total of 2263 students completed the questionnaire (77.4%) and a saliva sample was provided by 2131 participants. Failed MAOA u-variable number of tandem repeats (VNTR) genotype analyses and internal non-responses left 851 boys and 735 girls (total n = 1586) to be investigated. Alcohol use disorder identification test was used to measure hazardous alcohol consumption. MAOA u-VNTR was used to measure biological risk in interaction with poor family relations and experience of sexual abuse. The model was also adjusted for non-independent socioeconomic variables, separated parents, type of housing and parental unemployment. Results showed that the MAOA u-VNTR, in interaction with psychosocial risk factors, such as the quality of family relations and sexual abuse, was related to high alcohol consumption among adolescents. Girls, carrying the long MAOA u-VNTR variant showed a higher risk of being high alcohol consumers, whereas among boys, the short allele was related to higher alcohol consumption. The present study supports the hypothesis that there is a relation between MAOA u-VNTR and alcohol consumption and that this relation is modulated by environmental factors. Furthermore, the present study also supports the hypothesis that there is a sex difference in the G*E interaction.

Keywords: Abuse; MAOA; adolescent; alcohol; environment; gene

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1369-1600.2010.00238.x

Affiliations: 1: Centre for Clinical Research, Uppsala University, Central Hospital, Uppsala, Sweden 2: Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden

Publication date: April 1, 2011

bpl/adb/2011/00000016/00000002/art00015
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more