Skip to main content

Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study

Buy Article:

$51.00 plus tax (Refund Policy)



Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22–4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drinking and AD onset were obtained using standardized structured interviews. After subjects were genotyped for 2 ADH4 polymorphisms, single SNP case-control and haplotype analyses were conducted. Both variants—rs1800759 and rs1042364—and the A-A and C-G haplotypes were significantly related to AD across samples. Furthermore, associations with AD-related phenotypes and subtypes revealed a potential protective influence of this haplotype. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. While the rs1800759 and rs1042364 A-A haplotype had a potential protective influence on the risk for several AD-related phenotypes, this effect is rather small compared to functional variants of other alcohol or acetaldehyde-metabolizing enzymes like ALDH2*2 or ADH1B*2.

Keywords: ADH4; ADH4 haplotype analysis; Cloninger subtypes; alcohol dependence; alcohol dependence-related phenotypes; association genetic variants

Document Type: Research Article


Affiliations: 1: Department of Psychiatry, Psychosomatics and Psychotherapy, University Medical Center, Regensburg, Germany, 2: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany, 3: Department of Psychiatry and 4: Pomeranian Medical University, Szczecin, Poland, Department of Psychiatry, Johannes-Gutenberg University, Mainz, Germany, 5: Department of Psychiatry, Paracelsus-University, Salzburg, Austria and 6: International Hereditary Cancer Research,

Publication date: April 1, 2011


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more