Authors: Harshwardhan M. Mardikar,; Dhananjay Deo,; Deepa Raj,; Vishwanath Mohan,

Source: Vascular Disease Prevention, Volume 4, Number 3, August 2007 , pp. 250-259(10)

Publisher: Bentham Science Publishers

Abstract:

Asian Indians constitute almost one-fifth of the world population. A high prevalence of cardiovascular disease (CVD) and diabetes has been observed in this ethnic group in most of the studies conducted worldwide. It has been documented that migrant Indians have 3-4 times higher risk for CVD compared with Caucasians, 6 times higher than Chinese and 20 times higher than Japanese. Further, the incidence of CVD appears to be rising at an alarming rate in the Indian population in contrast to the decrease in incidence occurring in the developed countries. This predilection to CVD among Indians has been attributed to the so called “Asian Indian or South Asian Phenotype” which comprises of increased central obesity despite lower body mass index, increased insulin resistance, a characteristic dyslipdemia with low HDL-C (High Density Lipoprotein Cholesterol), increased triglycerides and excess of small dense LDL-C (Low Density Lipoprotein Cholesterol), decreased adiponectin and increased high sensitivity C-reactive protein levels. Clustering of metabolic abnormalities and high prevalence of metabolic syndrome and diabetes has also been reported among Indians.

This review discusses the role of several vascular risk factors in contributing to the excess of CVD in Asian Indians with a focus on some of the recent studies from the Indian subcontinent.

Keywords: Cardiovascular disease; Asian Indian Phenotype; diabetes; dyslipidemia; metabolic syndrome; hypertension; vascular disease; obesity; Asian Indians; South Asians

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156727007781388019

Publication date: 2007-08-01

More about this publication?

• Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.
  
  In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.
  
  Debates are encouraged in the correspondence section of this journal.
  The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.

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