Molecular Mechanisms of the Antiatherogenic Action of Adiponectin

Authors: Kobayashi, Kunihisa; Inoguchi, Toyoshi

Source: Vascular Disease Prevention, Volume 4, Number 1, February 2007 , pp. 7-9(3)

Publisher: Bentham Science Publishers

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Abstract:

Recently, many investigators have reported that adipocytes secrete a variety of bioactive substances, termed adipokines (adipocytokines), including tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), leptin, resistin, adiponectin and so on. Adiponectin is most abundant in the plasma and produced exclusively by adipocytes. This adipokine has been reported to be an exciting player in the field of energy homeostasis regulation. Furthermore, adiponectin has been shown to have antiatherogenic properties in epidemiological, in vitro and in vivo studies. This review summarizes the currently available information regarding this important biomolecule and discusses its feasibility for the treatment of atherosclerotic diseases.

Keywords: Adipokine; adiponectin; diabetes mellitus; atherosclerosis; insulin resistance; biglycan; subendothelial retention; low-density lipoprotein

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156727007779802714

Affiliations: 1: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University,3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Publication date: 2007-02-01

More about this publication?

Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

Debates are encouraged in the correspondence section of this journal.
The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.

Molecular Mechanisms of the Antiatherogenic Action of Adiponectin

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