The Role of Small, Dense Low-Density-Lipoproteins in Non-Coronary Forms of Atherosclerosis

Authors: Rizzo, Manfredi; Berneis, Kaspar

Source: Vascular Disease Prevention, Volume 3, Number 3, August 2006 , pp. 269-274(6)

Publisher: Bentham Science Publishers

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Abstract:

Small, dense low density lipoproteins (LDL) are associated with increased risk for cardiovascular disease and seem to be an important predictor of cardiovascular events and progression of coronary artery disease. In addition, the predominance of small dense LDL has been accepted as an emerging cardiovascular risk factor by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). Less data is available on the role of LDL size in the prevention of vascular diseases, including peripheral arterial disease, carotid artery disease and abdominal aortic aneurysm. The NCEP-ATP III stated that clinical non-coronary atherosclerosis carries a risk for coronary heart disease (CHD) equivalent to that of established CHD. The evaluation of LDL size in non-coronary atherosclerosis may potentially help identify patients at higher risk of vascular events.

Keywords: Small; dense LDL; coronary heart disease; atherosclerosis; prevention; peripheral arterial disease; carotid artery disease; abdominal aortic aneurysm

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156727006778019103

Affiliations: 1: Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita' di Palermo, Via del Vespro,141, 90127 Palermo, Italy.

Publication date: 2006-08-01

More about this publication?

Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

Debates are encouraged in the correspondence section of this journal.
The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.

The Role of Small, Dense Low-Density-Lipoproteins in Non-Coronary Forms of Atherosclerosis

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