Relationship Between Proinsulin Level and Cardiovascular Risk Factors Clustering: An Epidemiological Study

Authors: Jia, En-Zhi; Yang, Zhi-Jian; Chen, Shi-Wei; Qi, Guang-Yao; You, Chun-Fa; Ma, Jian-Feng; Zhang, Jing-Xin; Wang, Zhen-Zhen; Qian, Wei-Chong; Wang, Hai-Yan; Ma, Wen-Zhu

Source: Vascular Disease Prevention, Volume 2, Number 3, July 2005 , pp. 237-243(7)

Publisher: Bentham Science Publishers

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Abstract:

OBJECTIVE: An epidemiological study to explore the relationship between proinsulin and cardiovascular risk factor clustering. METHODS: 1196 subjects (533 men, 663 women; average age was 46.7 years) aged 35-59 in Pizhou city in Jiangsu province were randomly recruited. Fasting serum proinsulin was measured by a high sensitivity specific monoclonal antibody-based two-site enzyme immunoassay. RESULTS: The mean cardiovascular risk factor score was 0.97, 1.15, 1.53, and 2.04 (p = 0.000), and the rates of clustering of cardiovascular risk factors were 25.8%, 30.8%, 45.8% and 58.5% (p = 0.000) from the lowest to the highest quartile of proinsulin level, respectively. The Spearman correlation coefficient between proinsulin level and cardiovascular risk factors score was 0.308 (p = 0.000). By partial correlate analysis after adjusting for age, sex, body mass index and waist circumference the correlation was 0.2095 (p = 0.000). The results of non-conditional univariate logistic regression and multivariate stepwise logistic regression indicated that the concentration of proinsulin was associated with cardiovascular risk factor clustering (independent of age, sex, body mass index and waist circumference) and the odds ratio (95% confidence interval) was 1.656 (1.483 sim

1.851) and 1.381 (1.206 sim

1.582), respectively. CONCLUSIONS: There was a dose-response relationship independent of age, sex, body mass index and waist circumference between proinsulin and the clustering of cardiovascular risk factors in this Chinese middle-aged population.

Keywords: proinsulin cardiovascular disease risk factors epi

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1567270054368916

Affiliations: 1: Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China.

Publication date: 2005-07-01

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Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

Debates are encouraged in the correspondence section of this journal.
The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.

Relationship Between Proinsulin Level and Cardiovascular Risk Factors Clustering: An Epidemiological Study

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