Blocking Leukocyte Rolling: Does it have a Role in Disease Prevention?

Authors: Markus Sperandio; Barbel Lange-Sperandio; Otwin Linderkamp; Albrecht Leo

Source: Vascular Disease Prevention, Volume 1, Number 3, November 2004 , pp. 185-195(11)

Publisher: Bentham Science Publishers

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Abstract:

Selectins are important leukocyte adhesion molecules mediating the initial capture and rolling of leukocytes and therefore contributing to an effective recruitment of leukocytes to sites of inflammation. In animal models, blockade of P-, E-, or L-selectin-dependent leukocyte rolling has been shown to protect from several acute and chronic inflammatory diseases such as ischemia / reperfusion injury, asthma, psoriasis, and atherosclerosis. While selectins often act in an overlapping fashion novel pan-selectin antagonists have been developed with promising results in experimental studies. This led to the initiation of first clinical trials in patients with asthma and psoriasis. Interestingly, clinical trials aiming at blocking selectins in acute inflammatory diseases are still lacking, but patients suffering from stroke, myocardial infarction, or renal ischemia might benefit from a selectin blocking therapy if started early after onset of ischemia.

In conclusion, blocking selectin function may have a role in disease prevention for both acute and chronic inflammatory diseases. But, since selectins in humans functionally differ from selectins in other species, results from studies in nonhuman species should be carefully translated into clinical trials.

Keywords: selectins; leukocyte recruitment; ischemia; atherosclerosis; stroke; myocardial infarction

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1567270043404818

Affiliations: 1: Children's Hospital University of Heidelberg Im Neuenheimer Feld 150 69120 Heidelberg, Germany.

Publication date: 2004-11-01

More about this publication?

Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

Debates are encouraged in the correspondence section of this journal.
The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.

Blocking Leukocyte Rolling: Does it have a Role in Disease Prevention?

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