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Impact of Postprandial Remnant Lipoproteins on Coronary Artery Disease

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Abstract:

Increasing evidence suggests that postprandial remnants, including very-low-density lipoproteins and chylomicron remnants, are associated with coronary artery disease. A recently developed immunoseparation method provides a new approach for postprandial remnants analysis. Abnormal postprandial lipoprotein metabolism may cause a prothrombotic state and endothelial dysfunction. Postprandial remnant lipoproteins may accelerate smooth muscle cell proliferation, which may cause restenosis after coronary angioplasty. Recent studies have demonstrated the association between postprandial lipoprotein metabolism and insulin resistance, both of which increase the risk of coronary artery disease. We need to be aware of which agents, fibrates or statins, can adequately control postprandial remnant hyper-lipoproteinaemia. There is an urgent need to conduct large-scale, randomized, prospective studies focusing on postprandial lipid metabolism.

Keywords: chylomicron remnants; coronary artery disease; postprandial lipaemia; postprandial lipoproteins

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/1567270043480841

Affiliations: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo, 113-8519 Japan.

Publication date: March 1, 2004

More about this publication?
  • Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

    In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

    Debates are encouraged in the correspondence section of this journal.
    The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.
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