Authors: Chaer, Rabih A.; DeRubertis, Brian; Patel, Sheela; Lin, Stephanie C.; Kent, Craig K.; Faries, Peter L.

Source: Reviews on Recent Clinical Trials, Volume 1, Number 3, September 2006 , pp. 293-301(9)

Publisher: Bentham Science Publishers

Abstract:

Stroke is the third most common cause of death in the United States. There are approximately 700,000 strokes/year, eighty percent are ischemic, and 20-30% of ischemic strokes are secondary to carotid disease. Carotid stenosis is traditionally treated by carotid endarterectomy (CEA). Multicenter randomized controlled trials have shown that surgery significantly reduces the risk of ipsilateral stroke in patients with severe symptomatic and asymptomatic carotid stenosis. Endovascular techniques for treating carotid stenosis have been developed over recent years. Carotid angioplasty and stenting (CAS) with cerebral protection has become an alternative to CEA for high-surgical-risk patients and the procedure of choice for stenoses inaccessible by surgery. In this review we summarize the existing data regarding the traditional state of management of extracranial carotid artery stenosis, and compare these data to a critical analysis of the recent results of CAS.

Keywords: Stroke; Carotid; Stenosis; Endarterectomy; Angioplasty; Stent

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157488706778250159

Affiliations: 1: New York Presbyterian Hospital, Site Chief, Division of Vascular Surgery, Cornell University,Weill Medical College, Chief of Endovascular Surgery, Columbia University,College of Physicians and Surgeons, 525 East 68th St., Room P-705, New York, NY

Publication date: 2006-09-01

More about this publication?

• Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal's aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I - IV clinical trial studies, clinical investigations at all stages of development and therapeutics.
  
  The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.

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