AMPA Receptor Antagonists: Potential Therapeutic Applications
Authors: Mattes, Henri; Lingenhoehl, Kurt; Kalkman, Hans; Auberson, Yves; Renaud, Johanne; Schmutz, Markus; Orain, David
Source: Recent Patents on CNS Drug Discovery, Volume 1, Number 3, November 2006 , pp. 247-259(13)
Publisher: Bentham Science Publishers
Abstract:The current review will focus on the recent patents for AMPA receptor antagonists and their claims, evidence for their therapeutic effectiveness in the treatment of epilepsy and their potential role in psychiatric and neurodegenerative disorders. It will also highlight the proposed mechanisms of action and the implications thereof for our current understanding of the biomolecular basis of these pathologies. It will conclude with a summary of what we know, but also point out the remaining uncertainties, especially as this relates to the claims in the patent under discussion.
Document Type: Research article
Publication date: 2006-11-01
- Recent Patents on CNS Drug Discovery publishes review articles on recent patents in the field of CNS drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on CNS drug discovery is also included in the journal. The journal is essential reading for all researchers involved in CNS drug design and discovery.