Authors: ElSohly, Mahmoud A.; Gul, Waseem

Source: Recent Patents on Anti-Infective Drug Discovery, Volume 2, Number 3, November 2007 , pp. 222-232(11)

Publisher: Bentham Science Publishers

Abstract:

Malaria is the number one disease in the world responsible for 1-3 million deaths each year. The world wide number of malaria patients is estimated at 400 to 900 million. Approximately one third of the world's population lives in malaria-endemic areas, including Central and South America, Asia, and Africa.

Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae are malaria parasites responsible for infecting humans.

Mosquitoes that carry malaria parasites have become resistant to insecticides, and the deadliest parasites have become resistant to previously effective antimalarial drugs such as chloroquine, quinine and other clinically used agents.

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial agents, there is an urgent need for introducing new effective drugs.

This review presents the recent patents that reveal development of novel antimalarial drugs.

Keywords: Plasmodium falciparum; Plasmodium vivax; Plasmodium ovale and Plasmodium malariae; recent antimalarial agents; spiro and dispiro-trioxolanes; aminoquinolines; artemisinin derivatives; tryptanthrin; indoloquinazoline compounds; alkyl aryl carbonyl compounds

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157489107782497263

Publication date: 2007-11-01

More about this publication?

• Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.

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