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Therapeutic Interventions to Renin-Angiotensin-Aldosterone System, and Vascular Redox State

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It is well established that RAS plays a key role in the development of hypertension, cardiovascular and renal disease. On the other hand oxidative stress is a key feature in vascular homeostasis. Many of the cellular effects of Ang II appear to be mediated by ROS generated by NAD(P)H oxidase. In this review, we provide an overview of ROS physiology in human vessels especially in relation with RAS. We also discuss how therapeutic interventions on RAS affect redox signaling in the vascular wall at a clinical level with the discussion of recent patents.

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Keywords: Janus kinase; Mineralocorticoid receptor antagonists; Oxidative stress; Plasma renin activity; RAS; Reactive Oxygen Species; Renin-angiotensin system; Tissue necrosis factor; angiotensin-converting enzyme inhibitors; redox signaling; β blocker

Document Type: Research Article

Publication date: 2011-05-01

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  • Recent Patents on Cardiovascular Drug Discovery publishes review articles on recent patents in the field of cardiovascular drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on cardiovascular drug discovery is also included in the journal. The journal is essential reading for all researchers involved in cardiovascular drug design and discovery.
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