Authors: Andrikopoulos, George; Dasopoulou, Chryssanthi; Sakellariou, Dimitris; Tzeis, Stylianos; Koulouris, Spyridon; Kranidis, Athanasios; Kappos, Kostas; Manolis, Antonis S.

Source: Recent Patents on Cardiovascular Drug Discovery, Volume 1, Number 3, November 2006 , pp. 277-282(6)

Publisher: Bentham Science Publishers

Abstract:

The role of heart rate reduction in the management of myocardial ischemia and chronic stable angina is pivotal. However, broad use and appropriate dosing of commonly used rate-slowing drugs is limited by their poor tolerability. Ivabradine is a selective inhibitor of the If currents of the sinoatrial node cells. If currents activity determines the slope of the depolarization curve towards the threshold level controlling heart rate in patients with sinus rhythm. Ivabradine, a compound of the benzocyclobutane (S 16257), exhibits a unique specificity for the If current and has a more favorable profile of adverse reactions compared to other If inhibitors. Accordingly, ivabradine has been used in the treatment of stable angina, where it presented anti-anginal and antiischemic effects equivalent to the effects of atenolol and amlodipine. Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction. Thus, the clinical value of ivabradine, which has completed clinical development for stable angina, is expected to exceed its role in the treatment of myocardial ischemia. In this context, ivabradine, promising efficacious and safe pharmacological management of heart rate, is a huge step in cardiovascular therapeutics.

Keywords: Ivabradine; stable angina; If currents; heart rate; sinoatrial node

Document Type: Research article

Publication date: 2006-11-01

More about this publication?

• Recent Patents on Cardiovascular Drug Discovery publishes review articles on recent patents in the field of cardiovascular drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on cardiovascular drug discovery is also included in the journal. The journal is essential reading for all researchers involved in cardiovascular drug design and discovery.

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• In this Subject: Cardiovascular Medicine ,  Pharmacology ,  Law
• By this author: Andrikopoulos, George ;  Dasopoulou, Chryssanthi ;  Sakellariou, Dimitris ;  Tzeis, Stylianos ;  Koulouris, Spyridon ;  Kranidis, Athanasios ;  Kappos, Kostas ;  Manolis, Antonis S.

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