Author: Inagi, Reiko

Source: Recent Patents on Cardiovascular Drug Discovery, Volume 1, Number 2, June 2006 , pp. 151-159(9)

Publisher: Bentham Science Publishers

Abstract:

Oxidative stress is a common denominator in many aspects of the pathogenesis of atherosclerosis and cardiovascular diseases. Some drugs, such as vitamin C, vitamin E, and a free radical scavenger, edaravone, are prescribed with oxidative stress as their main target. Furthermore, of the drugs in current clinical use, such as anti-hypertension reagents including angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB), and antihyperlipidemic reagents like statins, protect various organs, e.g., vessel, brain, heart, and kidney, via anti-oxidative stress effects in addition to their original pharmacological properties. While results of clinical trials of anti-oxidative stress reagents in patients with cardiovascular disease are contradictory to date, this may be explained by a variety of reasons such as an inadequate study design. More competent anti-oxidative reagents are awaited, and superoxide dismutase mimetics, thiols, xanthine oxidase and NAD(P)H oxidase inhibitors, which regulate intracellular redox reaction and subsequently inhibit oxidative stress, are among promising candidates of future drug developments currently receiving much interest. In this review, the current advances will be highlighted in development of novel anti-oxidative therapeutic approaches against cardiovascular diseases.

Keywords: Angiotensin-converting enzyme (ACE) inhibitor; angiotensin receptor blocker (ARB); diabetes mellitu; endothelium; hypertension; ischemic heart disease; kidney failure; NAD(P)H oxidase; nitric oxide (NO); reactive oxygen species (ROS)

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157489006777442450

Affiliations: 1: Institute of Medical Sciences, Tokai University School of Medicine, Bohseidai, Isehara Kanagawa 259- 1193, Japan.

Publication date: 2006-06-01

More about this publication?

• Recent Patents on Cardiovascular Drug Discovery publishes review articles on recent patents in the field of cardiovascular drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on cardiovascular drug discovery is also included in the journal. The journal is essential reading for all researchers involved in cardiovascular drug design and discovery.

Related content

• In this: publication
• By this: publisher
• In this Subject: Cardiovascular Medicine ,  Pharmacology ,  Law
• By this author: Inagi, Reiko

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers