Authors: Han, Kyu-Yeon; C. Fahd, Daoud; Tshionyi, Makambo; Allemann, Norma; Jain, Sandeep; Chang, Jin-Hong; T. Azar, Dimitri

Source: Protein and Peptide Letters, Volume 19, Number 12, December 2012 , pp. 1334-1339(6)

Publisher: Bentham Science Publishers

Abstract:

The cornea is physiologically avascular. Following a corneal injury, wound healing often proceeds without neovascularization (NV); however, corneal NV may be induced during wound healing in certain inflammatory, infectious, degenerative, and traumatic states. Such states disrupt the physiologic balance between pro-angiogenic and antiangiogenic mediators, favoring angiogenesis. Contributors to such states are matrix metalloproteinases (MMPs), which are key factors in both extracellular matrix remodeling and angiogenesis. Similarly, vascular endothelial growth factor A (VEGF-A) and basic fibroblast growth factor (bFGF) exert pro-angiogenic effects. Here, we elaborate on the facilitative role of MMPs-specifically Membrane Type 1 MMP (MT1-MMP, MMP14)-in corneal NV. Additionally, we provide new insight into the signaling relating to MT1-MMP, Ras, and ERK in the bFGF-induced VEGF-A expression pathways within the corneal fibroblasts.

Keywords: Basic FGF; corneal angiogenesis; ERK; MT1-MMP; Ras; VEGF-A; homeostasis; pro-angiogenic effect; Basic fibroblast growth factor (bFGF); vascular endothelial growth factor

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986612803521639

Publication date: 2012-12-01

More about this publication?

• Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

Related content

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology
• By this author: Han, Kyu-Yeon ;  C. Fahd, Daoud ;  Tshionyi, Makambo ;  Allemann, Norma ;  Jain, Sandeep ;  Chang, Jin-Hong ;  T. Azar, Dimitri

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers