Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139
Keywords: Grb7 protein; Molecular dynamics simulations; NMR refinement; SH2 domain; breast cancer; focal adhesion kinase (FAK); ligand-bound Grb7-SH2 domain; signaling pathways; tumor tissues; water refinement
Document Type: Research Article
Publication date: 2012-08-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.