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SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450

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Abstract:

Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human cytochrome P450 SNPs (Single Nucleotide Polymorphisms) based on the SVM flanking sequence method; SCYPPred can rapidly yield the desired results by using the amino acid sequences information alone. The web-server is accessible to the public at http://snppred.sjtu.edu.cn. Hopefully SCYPPred could be a useful bioinformatics tool for elucidating the mutation probability of a specific CYP450 enzyme.





Keywords: Cytochrome P450; DNA-sequence; FN; Human cytochrome; KEGG; Mutation Probability; RBF; SCYPPred; SNPs; SVM; SVM flanking; Single Nucleotide Polymorphisms; Vector encoding; archaea; benchmark dataset; hemoproteins

Document Type: Research Article

DOI: https://doi.org/10.2174/092986612798472785

Publication date: 2012-01-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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