Can Enzyme Engineering Benefit from the Modulation of Protein Motions? Lessons Learned from NMR Relaxation Dispersion Experiments
Keywords: CPMG; Cyclophilin A; NMR Relaxation; NMR spectroscopy; Pin1; Protein Motions; Ribonuclease A; adenylate kinase; amino acid networks; biocatalysts; de novo; dihydrofolate reductase; dispersion experiments; dispersion tools; disruptors; drug development and nanotechnology; enablers; enzyme catalysis; flexibility-function; nanoscale machines; protein engineering; rational mutagenesis; relaxation dispersion; residue motion; semi-random mutagenesis; structure-function
Document Type: Research Article
Publication date: 2011-04-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.