Role of Protein Conformational Dynamics in the Catalysis by 6-Hydroxymethyl-7, 8-Dihydropterin Pyrophosphokinase
Keywords: 15N relaxation; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; AMPCPP; ARGININE 82 AND ARGININE 92; ARGININE 82 AND ARGININE 93; Bisubstrate enzyme; DHFS; DHNA; HP analogue; HPPK; MgATP binding; Michaelis complex; NMR; PDB code; X-ray crystallography; apo enzyme; bisubstrate enzyme; de novo; dihydrofolate reductase; enzymatic catalysi; enzymatic catalysis; enzyme-substrate complex; fluorometry; folate biosynthesis; ligand-bound; protein dynamics; protein's hydrophobic core; ternary complex
Document Type: Research Article
Publication date: 2011-04-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.