Predicting Caspase Substrate Cleavage Sites Based on a Hybrid SVMPSSM Method
Keywords: B-cell epitope; BLOSUM62 matrix; BLOSUM62 matrix profile; CASBAH database; CAspase; Caspase; GalNAc-transferase; HIV protease; Hybrid SVMPSSM Method; MEROPS protease database; Matthews's Correlation Coefficient; P4-P3-P2-P1; PSSM profiles; Position Specific Score Matrix; SVM; SVM-PSSM method; Substrate dataBAse; alanine; alpha-turn types; benchmark dataset; caspase 3; cathepsin B; crossvalidation; cysteine proteases; granzyme B; jackknife test; mammalian cell death; orthonormal binary encoding; radial basis function; serine hydrolases; substrate cleavage sites prediction; support vector machine; valine
Document Type: Research Article
Publication date: 2010-12-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.