Comparing the Interaction of Cyclophosphamide Monohydrate to Human Serum Albumin as Opposed to Holo-Transferrin by Spectroscopic and Molecular Modeling Methods: Evidence for Allocating the Binding Site
Keywords: Arg149; FRET; Far-UV CD experiments; Genetic Algorithm and local Search Parameters; His146; Holo-Transferrin; Human Serum Albumin; Human serum albumin; Jasco spectrophotometer; Lys195; Lys199; Molecular Modeling Methods; Protein Data Bank; Spectroscopic; Stern-Volmer plot; Transferrins; Trp214; Tyr411; UV absorption; Xenon lamp; albumin; anti-cancer agents; apo-hTf; circular dichroism (CD) spectroscopie; cyclophosphamide; ethanol; fluorescence emission spectrum; fluorescence resonance energy transfer; fluorophores; globulin; glycoproteins; holo-hTf; human Serum transferrin; human serum transferrin; molecular modeling; phosphate buffer solution; serum transferrins; spectroscopy methods; thermostat bath; tryptophan; tryptophan residues; tyrosyl; tyrosyl groups; α-helix
Document Type: Research Article
Publication date: 2010-12-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.