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Lectin Glycoarray Technologies for Nanoscale Biomedical Detection

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Microarray technologies have begun to feature widely in biomedical science. These techniques, allow for high throughput and quantitative analysis of protein-carbohydrate interactions. Lectin and antibody have been evaluated with these new techniques which extend to the detection of viruses and bacteria. This review outlines some of the basic principles of ‘glycoarrays’ and illustrates their recent applications. Moreover, the review also gives an overview about a recently launched powerful detection platform using lectin microarrays with a potential to revolutionize the use of lectins in biomedical diagnosis and glycomics in general. In addition, two analytical techniques including mass spectrometry and glycan microarrays expected to play important role to characterize binding profile of new lectins are described in brief. Finally, strong and weak points of lectins as biorecognition molecules currently used in biomedical diagnosis are shown with conclusions drawn from molecular modelling of biorecognition events.

Keywords: (FRET); (FT-ICR); (ITC); (SAMs); (WGA); CDR-2; CDR-3; CEA; EBA; Escherichia coli; Kd values; Lectin; MALDI MS; MES; MUC1; Microarray; NMR; PDB; SPR; X-ray crys-tallography; carbohydrate; carbohydrate-protein interaction; cytokine; glycoarray; glycome; glycospacer; glycosylation; lectins; mass; mass spectrometric techniques; mass spectrometry; severse transcriptase

Document Type: Research Article

Publication date: November 1, 2010

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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