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Adsorption and Bioactivity of Tyrosine Hydroxylase on Gold Surfaces and Nanoparticles

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Abstract:

Tyrosine hydroxylase is studied in terms of adsorption behaviour on gold surfaces and various passivating layers. Results reveal differences in layer formation, where mercaptoundecanoic acid-coated gold shows the best potential in terms of adsorbed mass. Nanoparticles with this coating are subsequently tested for enzymatic activity, which remains at attenuated levels.





Keywords: (L-DOPA); (MUA); Citrate; D-fplots; Gold nanoparticles; L-DOPA; Parkinson's disease; QCM; QCM-Z500; TRANSIL; Tyrosine Hydroxylase; adsorption; electrostatic; enzymatic; enzymatic activity; kinetic; nanoparticles; pH; pKa; quartz crystals; recombinant; recombinant human tyrosine hydroxylase isoform 1 (hTH1); stability

Document Type: Research Article

Publication date: 2010-11-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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