Synthesis of N-Succinyl-L,L-Diaminopimelic Acid Mimetics Via Selective Protection
Abstract:The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,Ldiaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.
Document Type: Research Article
Publication date: March 1, 2010
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