The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein
Abstract:Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.
Document Type: Research Article
Publication date: December 1, 2009
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