Non-Globular Structures of Tandem Repeats in Proteins

Authors: Matsushima, Norio; Tanaka, Takanori; Kretsinger, Robert H.

Source: Protein and Peptide Letters, Volume 16, Number 11, November 2009 , pp. 1297-1322(26)

Publisher: Bentham Science Publishers

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Abstract:

There are two classes of tandem repeats in proteins - globular and non-globular. There are two subclasses of non-globular repeats. The first, such as collagen, form stable helices. Members of the second are flexible and somewhat disordered both in vitro and in vivo. This review focuses on this second subclass.

Keywords: Tandem repeats; intrinsically unstructured protein; structural change; ligand interaction; rapid evolution; concerted evolution

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986609789353745

Publication date: 2009-11-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.