Antinociceptive Activity of Lectins from Diocleinae Seeds on Acetic Acid-Induced Writhing Test in Mice
Authors: Holanda, Fernanda R.; Coelho-de-Sousa, Andrelina N.; Assreuy, Ana M.S.; Leal-Cardoso, Jose H.; Pires, Alana F.; do Nascimento, Kyria S.; Teixeira, Cicero S.; Cavada, Benildo S.; Santos, Claudia F.
Source: Protein and Peptide Letters, Volume 16, Number 9, September 2009 , pp. 1088-1092(5)
Publisher: Bentham Science Publishers
Abstract:Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate recognition.
Document Type: Research Article
Publication date: 2009-09-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.