Skip to main content

Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked Northogonally protected dipeptidomimetics by the condensation of Nα-Fmoc α-halomethylketones with thiourea and Boc/Z-α-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4- amino thiazole moiety have also been synthesized following the similar protocol.





Keywords: N-Fmoc-4-amino-thiazolyl derivatives; Nα-Fmoc-haloketones; heteroaryl alanine derivatives and dipeptide thiozoles

Document Type: Research Article

Publication date: 2009-09-01

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more