Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms
Authors: de Paula, Rafael C.; Castro, Helena Carla; Rodrigues, Carlos Rangel; Melo, Paulo Assis; Fuly, Andre Lopes
Source: Protein and Peptide Letters, Volume 16, Number 8, August 2009 , pp. 899-907(9)
Publisher: Bentham Science Publishers
Abstract:Phospholipases A2 enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA2s including biological and structural features, interaction with binding receptors, inhibitors used on structure- function relationship studies and highlighting the mechanism of action and role of the snake venom PLA2s products, the lysophosphatidylcholine.
Document Type: Research Article
Publication date: August 1, 2009
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.