Influence of Quaternary Conformation on the Biological Activities of the Asp49-phospholipases A2s from Snake Venoms

Authors: Magro, Angelo J.; Fernandes, Carlos A.H.; dos Santos, Juliana I.; Fontes, Marcos R.M.

Source: Protein and Peptide Letters, Volume 16, Number 8, August 2009 , pp. 852-859(8)

Publisher: Bentham Science Publishers

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Abstract:

One of the main components of snake venoms are the Asp49-phospholipases A2, also known as svPLA2s. The study of these toxins is a matter of great scientific interest due to their wide variety of biological effects. In this work we present strong evidences found in literature and other aspects which strengthen the importance of quaternary assembly for understanding the activities and molecular evolution of svPLA2s.





Keywords: Phospholipase A2; oligomerization; quaternary conformation; snake venom

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986609788923301

Publication date: August 1, 2009

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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