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Membrane Permeabilization by Multivalent Anti-Microbial Peptides

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Abstract:

Antimicrobial peptides (AMP's) are promising compounds in the battle against antibiotic resistant pathogens. Many AMP's function by interacting with the bacterial membrane and selectively permeabilizing it. Improvements are desired in the potency and the in vivo stability of the AMP's. Both aspects have been approached by the preparation of multivalent versions of AMP's that contain several copies of the peptide attached to a scaffold or core molecule. Both short and long sequences have been used and in selected cases major increases in antibacterial activity, membrane permeabilization potency and in vivo stability have been obtained.





Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986609788681841

Publication date: July 1, 2009

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
ben/ppl/2009/00000016/00000007/art00005
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