Hsp70 Structure, Function, Regulation and Influence on Yeast Prions
Abstract:Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.
Document Type: Research Article
Publication date: June 1, 2009
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