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Design and Synthesis of Substrates for Model Ribosomal Reactions

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Abstract:

2'/3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-Ado (1) and its deoxy analog: 3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-2'- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2'-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.





Keywords: Design; nucleoside synthesis; peptide synthesis; ribosome catalysis

Document Type: Research Article

DOI: https://doi.org/10.2174/092986609787848009

Publication date: 2009-04-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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