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EQCM Biosensors Based on DNA Aptamers and Antibodies for Rapid Detection of Prions

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Abstract:

Novel affinity biosensors for detecting cellular prions, PrPC, based on DNA aptamers and antibodies immobilized onto the carbon nanotubes have been designed and compared in accordance with their binding ability and analytical performance. The biosensors allowed us to detect PrPC with the limits of detection of 20 to 50 pM.





Keywords: DNA aptamers; Prion proteins; antibodies; biosensor; electrochemical quartz crystal microbalance; multiwalled carbon nanotubes

Document Type: Research Article

DOI: https://doi.org/10.2174/092986609787848090

Publication date: 2009-04-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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