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Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors

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NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.

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Keywords: NPTX-594; Spider toxin; cricket bioassay; fluorescent label; glutamate receptor (GluR); thiol-containing fluorophore

Document Type: Research Article

Publication date: 2009-03-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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