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Neutrophil Proteome: Lessons from Different Standpoints

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The present review brings a timeline of some of the major steps given throughout the years towards the development of our knowledge regarding the biology of the neutrophil. The contribution of early articles and their elementary biochemical approach is highlighted. The importance of the development of proteomic techniques is paralleled to the shift in neutrophil research towards high throughput molecular methods. As a last change of standpoint, the study of the neutrophil is presented integrated with other lifesciences technologies such as lipidomics, genomics and systems biology. The paper also brings a perspective/ tendency overview at the same time that it discusses some of the difficulties encountered in the research of the neutrophil.

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Keywords: Neutrophil; mass spectrometry; proteome; two-dimensional electrophoresis

Document Type: Research Article

Publication date: 2008-09-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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