Synthesis and Structural Analysis of 6-Aminobicyclo[2.2.1]heptane-2- carboxylic Acid as a onformationally Constrained γ-Turn Mimic
Authors: Park, Jin-Seong; Kim, Kyoung R.; Nam, Hye Young; Yeom, Chang-Eun; Chough, Chieyeon; Kwon, Soon Ho; Ro, Seonggu; Shin, Dong-Kyu; Kim, B. Moon
Source: Protein and Peptide Letters, Volume 15, Number 9, September 2008 , pp. 980-984(5)
Publisher: Bentham Science Publishers
Abstract:An efficient asymmetric synthesis of 6-aminobicyclo[2.2.1]heptane-2-carboxylic acid as a novel γ-turn mimic has been achieved. Structural analysis of the γ-amino acid derivative was carried out using 1H NMR spectroscopy and intramolecular hydrogen bonding between side chain amides confirmed the turn structure, which had been predicted by Ab initio computational study.
Document Type: Research Article
Publication date: September 1, 2008
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