Targeting the Plasmepsin 4 Orthologs of Plasmodium sp. with “Double Drug” Inhibitors
Keywords: Double Drug; Plasmepsin; Proenzyme; a combination of two molecular entities in one compound that kill a pathogen by two mechanisms; a compound that blocks the growth of the malarial parasite in culture; a word derived from Plasmodium pepsin; antimalarial; proteolytic enzyme from the Plasmodium species; statine; the naturallyoccurring amino acid derivative (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid
Document Type: Research Article
Publication date: 2008-09-01
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.