Structural Bioinformatics Study of PNP from Listeria monocytogenes
Authors: Timmers, L. F.S.M.; Caceres, R. A.; Basso, L. A.; Santos, D. S.; De Azevedo, Jr., W. F.
Source: Protein and Peptide Letters, Volume 15, Number 8, August 2008 , pp. 843-849(7)
Publisher: Bentham Science Publishers
Abstract:This work describes for the first time a model of Purine Nucleoside Phosphorylase from Listeria monocytogenes (LmPNP). We modeled the complexes of LmPNP with ligands in order to determine the structural basis for specificity. Comparative analysis of the model of LmPNP allowed identification of structural features responsible for ligand affinities.
Document Type: Research Article
Publication date: August 1, 2008
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.