A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria
Abstract:A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca2+ channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.
Document Type: Research Article
Publication date: 2008-07-01
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