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A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria

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Abstract:

A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca2+ channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.





Keywords: L-type Ca 2+ channels; Phoneutria; Spider toxin; amino acid sequences; molecular modeling; neurotoxin

Document Type: Research Article

DOI: https://doi.org/10.2174/092986608785133708

Publication date: 2008-07-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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