Albumin Competitively Inhibits Glycation of Less Abundant Proteins

Authors: Bhonsle, Hemangi S.; Singh, Sameer K.; Srivastava, Ghanshyam; Boppana, Ramanamurthy; Kulkarni, Mahesh J.

Source: Protein and Peptide Letters, Volume 15, Number 7, July 2008 , pp. 663-667(5)

Publisher: Bentham Science Publishers

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Abstract:

Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show that albumin competitively inhibits the glycation of less abundant proteins. This study suggests that at least in the initial stages of diabetes, albumin may protect other proteins from glycation.

Keywords: insulin; glucose; diabetes; vascular complication; MALDI-TOF-MS

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986608785133690

Publication date: 2008-07-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.