Role of Polyglycine Repeats in the Regulation of Glycogen Synthase Kinase Activity

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Abstract:

Glycogen synthase kinase (GSK3) activity present in one cell is the consequence of the sum of the activities of two different proteins called GSK3α and GSK3β. These isoenzymes are coded by two different genes and share an almost identical sequence at their catalytic domain, but differ in the sequence of putative regulatory regions. In this review, we propose that glycine repeats present only in GSK3α may result in the different cleavage of both isoenzymes by the protease calpain, a cleavage that modifies GSK3 activity.





Keywords: GSK3 activity; calpain; polyglycine repeats

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986608784966967

Publication date: July 1, 2008

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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