Structure-Activity Relationships of the Dimeric Analogues of Endomorphin-2 with Different Lengths of Spacers
Abstract:In the present study, seven novel dimeric analogues of endomorphin-2 with longer spacers were designed and synthesized. Through dimerization, their affinity for δ-opioid receptor was mostly increased, especially the δ-opioid receptor preferred dimeric analogue, DEM12. The results were confirmed by the in vitro bioassay. The structure-activity relationships were also discussed.
Document Type: Research Article
Publication date: 2008-03-01
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