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Crystallization and Preliminary X-Ray Analysis of Anti-Obesity Peptide Hormone Oxyntomodulin

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Abstract:

Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 Å resolution and belongs to space group P213 with unit-cell parameters a=b=c= 48.44 Å, α=β=γ=90°. Preliminary analysis indicates a trimer packing in one asymmetric unit.





Keywords: GLP-1; Oxyntomodulin; crystallization; diabetes; glucagon; obesity; synthesis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986608783489643

Publication date: February 1, 2008

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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