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In Silico Modulation of HMGN-1 Binding to Histones and Gene Expression by Interplay of Phosphorylation and O-GlcNAc Modification

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Abstract:

Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.





Keywords: HMGN-1; Yin Yang sites; chromatin; histones; nucleosome; post-translational modifications

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986608783489607

Publication date: February 1, 2008

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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