Processing of DNA Replication and Repair Intermediates by the Concerted Action of RecQ Helicases and Rad2 Structure-Specific Nucleases

Authors: Brosh Jr., Robert M.; Sharma, Sudha; Sommers, Joshua A.

Source: Protein and Peptide Letters, Volume 15, Number 1, January 2008 , pp. 89-102(14)

Publisher: Bentham Science Publishers

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Abstract:

Processing of DNA replication and repair intermediates is a critical aspect of genome stability maintenance. The coordinated action of RecQ-like helicases with structure-specific nucleases such as Flap Endonuclease 1 plays an important role in the processing of certain DNA structures associated with the replication fork, DNA repair, or telomeres. We will summarize our current understanding of how and in what context these interactions take place, with a particular emphasis on the mechanisms of RecQ helicases in processing of key DNA replication and repair intermediates by their protein interactions with FEN-1 and related structure-specific nucleases.

Keywords: Helicase; nuclease; werner syndrome; bloom syndrome; DNA repair; replication

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986608783330369

Publication date: 2008-01-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.