Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
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Document Type: Research Article
Publication date: 2008-01-01
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