Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin
Authors: Franz, Thomas; Ruggeberg, Sabrina; Horn, Peter; Li, Xinping; Vajkoczy, Peter
Source: Protein and Peptide Letters, Volume 15, Number 1, January 2008 , pp. 43-46(4)
Publisher: Bentham Science Publishers
Abstract:During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
Document Type: Research Article
Publication date: January 1, 2008
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