Skip to main content

COILCHECK: An Interactive Server for the Analysis of Interface Regions in Coiled Coils

Buy Article:

$55.00 plus tax (Refund Policy)

Coiled coils are important structural modules and domains of protein-protein interactions. Further, they provide the required framework to proteins, like kinesins, myosins and SNAREs, which are either structural or involved in transport of biomolecules. We provide an interactive webserver to measure the strength of interactions between two helices involved in coiled coils. Interactions are measured using non-bonded and electrostatic interactions and the presence of hydrogen bonds and salt bridges. The sum of these interactions is expressed as psuedoenergy, whose ranges have been standardized using all structural entries that are classified to contain coiled coils. The results are displayed conveniently as energy per residue along with options to obtain detailed list of different types of interactions. This webserver can be useful to assess the strength of coiled coil regions, to recognize weak and strong regions, to rationalize the phenotypic behaviour of single residue mutations as well as to design mutation experiments. COILCHECK webserver can be accessed from http://caps.ncbs.res.in/coilcheck/.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Energy calculations; point mutations; protein stability; structural proteins; structure assessment

Document Type: Research Article

Publication date: 2008-01-01

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more